Sodium 1-(12-hydroxy)octadecanyl sulfate, an MMP2 inhibitor, isolated from a tunicate of the family Polyclinidae

Masaki Fujita; Yoichi Nakao; Shigeki Matsunaga; Teruaki Nishikawa; Nobuhiro Fusetani

doi:10.1021/np020250o

Sodium 1-(12-hydroxy)octadecanyl sulfate, an MMP2 inhibitor, isolated from a tunicate of the family Polyclinidae

J Nat Prod. 2002 Dec;65(12):1936-8. doi: 10.1021/np020250o.

Authors

Masaki Fujita¹, Yoichi Nakao, Shigeki Matsunaga, Teruaki Nishikawa, Nobuhiro Fusetani

Affiliation

¹ Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, the University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

PMID: 12502345
DOI: 10.1021/np020250o

Abstract

Sodium 1-(12-hydroxy)octadecanyl sulfate (1) was isolated from a marine tunicate as a matrix metalloproteinase 2 (MMP2) inhibitor.(1) The structure was elucidated by a combination of spectroscopic and chemical methods. Compound 1 inhibited MMP2 with an IC(50) value of 9.0 microg/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkanes / chemistry
Alkanes / isolation & purification*
Alkanes / pharmacology
Animals
Chromatography, High Pressure Liquid
Fluorescent Dyes / pharmacology
Inhibitory Concentration 50
Matrix Metalloproteinase Inhibitors*
Molecular Structure
Protease Inhibitors / chemistry
Protease Inhibitors / isolation & purification*
Protease Inhibitors / pharmacology
Spectrometry, Mass, Fast Atom Bombardment
Stereoisomerism
Tissue Inhibitor of Metalloproteinase-2 / pharmacology
Urochordata / chemistry*

Substances

Alkanes
Fluorescent Dyes
Matrix Metalloproteinase Inhibitors
Protease Inhibitors
sodium 1-(12-hydroxy)octadecanyl sulfate
Tissue Inhibitor of Metalloproteinase-2